If absolutely necessary, it can be used after the first trimester of pregnancy. Few data exist on use in pregnancy, and pyrantel pamoate is nonembryotoxic in animals. Although no specific data exist on its use in children younger than 2 years of age, no age-related problems have been documented. Pyrantel pamoate should be used with caution in people with hepatic dysfunction. Because of poor absorption from the gastrointestinal tract, side effects are restricted to infrequent occurrence of abdominal pain, diarrhea, dizziness, insomnia, rash, and headache. Paralyzed worms are expelled with intestinal peristalsis. The agent is nonvermicidal but causes depolarizing neuromuscular blockade of helminth musculature. Pyrantel pamoate is ineffective for trichuriasis. A single-dose regimen is sufficient for ascariasis and trichostrongylosis, but one dose daily on 3 consecutive days is required for hookworm infection. This drug has been supplanted by the benzimidazoles, except for its continued popularity for the treatment of enterobiasis. Pyrantel pamoate, a broad-spectrum anthelmintic drug, is available only as an over-the-counter oral suspension in the United States. Ryan, in Principles and Practice of Pediatric Infectious Diseases (Fifth Edition), 2018 Pyrantel Pamoate.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |